![]() Here, we report the rational engineering of aptamer TD05 into multimeric forms reactive with the BCR that may be useful in biomedical applications. Aptamers are small oligonucleotides that can specifically bind to a wide range of target molecules and offer some advantages over antibodies as therapeutic agents. ![]() No approved therapies target the hallmark of the B cell, its mIgM, also known as the B-cell receptor (BCR). ![]() Long-term survival still eludes most patients with leukemia and non-Hodgkin’s lymphoma. ![]()
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